Microstimulation of the Human Substantia Nigra Alters Reinforcement Learning
نویسندگان
چکیده
منابع مشابه
Microstimulation of the human substantia nigra alters reinforcement learning.
Animal studies have shown that substantia nigra (SN) dopaminergic (DA) neurons strengthen action-reward associations during reinforcement learning, but their role in human learning is not known. Here, we applied microstimulation in the SN of 11 patients undergoing deep brain stimulation surgery for the treatment of Parkinson's disease as they performed a two-alternative probability learning tas...
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Neuronal firing in the substantia nigra (SN) immediately following reward is thought to play a crucial role in human reinforcement learning. As in Ramayya et al. (2014a) we applied microstimulation in the SN of patients undergoing deep brain stimulation (DBS) for the treatment of Parkinson's disease as they engaged in a two-alternative reinforcement learning task. We obtained microelectrode rec...
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Neuronal firing in the substantia nigra (SN) immediately following reward is thought to play a crucial role in human reinforcement learning however direct evidence for this relation is lacking. We applied microstimulation in the SN of patients undergoing deep brain stimulation (DBS) for the treatment of Parkinson’s disease as they engaged in reinforcement learning. Microstimulation during the 5...
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Editor's Note: These short, critical reviews of recent papers in the Journal, written exclusively by graduate students or postdoctoral fellows, are intended to summarize the important findings of the paper and provide additional insight and commentary. For more information on the format and purpose of the Journal Club, please see Review of Ramayya et al. In a world rich with stimuli and potenti...
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Characterization of the human brain proteome is a critical area of research. While examination of the human cortex has provided some insight, very little is known about the proteome of the human midbrain, which demonstrates substantial loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) in Parkinson's disease (PD). Therefore, characterization of this region is essential to...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2014
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.5445-13.2014